Predicting drug-target interactions using restricted Boltzmann machines

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چکیده

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Predicting drug-target interactions using restricted Boltzmann machines

MOTIVATION In silico prediction of drug-target interactions plays an important role toward identifying and developing new uses of existing or abandoned drugs. Network-based approaches have recently become a popular tool for discovering new drug-target interactions (DTIs). Unfortunately, most of these network-based approaches can only predict binary interactions between drugs and targets, and in...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2013

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/btt234